Aptamer Details

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Insulin Receptor Antibody (MA20) (#1) (ID# 7474)

Aptamer Chemistry: DNA

Target: Insulin Receptor Antibody (MA20)

Antigen/Target Category: Antibody

Affinity (Kd): 30 nM (reported value)

Binding Conditions/Buffer: Binding buffer: 30 mM Tris-HCl (pH 7.5), 150 mM NaC1, 10 mM MgC1₂, 2 mM dithiothreitol, and 1.0% BSA

Binding Temp: RT°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 86

Molecular Weight: 50020.06

Extinction Coefficient: 843600

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Lee, Seong-Wook and Sullenger, Bruce A. "Isolation of a Nuclease-resistant Decoy RNA That Selectively Blocks Autoantibody Binding to Insulin Receptors on Human Lymphocytes." Journal of Experimental Medicine, 184 (1996): 315-324.

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