Aptamer Details

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Tumour Marker MUC1 (S1.6) (ID# 7491)

Aptamer Chemistry: DNA

Target: Tumour Marker MUC

Antigen/Target Category: Peptide

Affinity (Kd): 0.2131 nM (reported value)

Binding Conditions/Buffer: Binding Buffer (0.2 M NaHCO3 and 0.5 M NaCl (pH 7.4))

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: Kd values given in Table 2 of reference article may have been miscalculated. Using the kd and ka given in Table 2 of the reference, we have calculated the above Kd value from Kd=(kd/ka).

Sequence ():

Length: 72

Molecular Weight: 22336.6

Extinction Coefficient: 737600

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Ferreira, C., et al. "DNA Aptamers That Bi nd to MUC1 Tumour Marker: Design and Characterization of MUC1-Binding Single-Stranded DNA Aptamers." Tumor Biology, 27(2006): 289ƒ??301.

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