Aptamer Details

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Receptor Tyrosine Kinase (RET) Mutant (D4) (ID# 7500)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: 2'-F-RNA

Target: Receptor Tyrosine Kinase (RET) Mutant

Antigen/Target Category: Protein

Affinity (Kd): 35 nM (reported value)

Binding Conditions/Buffer: Selection buffer: RPMI 1640

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Binds to both PC12/MEN2A and PC12/MEN2B.

Sequence ():

Length: 50

Molecular Weight: 16281.84

Extinction Coefficient: 511900

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Cerchia, Laura, et al. "Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase." PLoS Biology, 3 (2004): e123

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