Aptamer Details

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Human Nonpancreatic Secretory Phospholipase A2 (Aptamer 15) (ID# 7536)

Aptamer Chemistry: DNA

Target: Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2)

Antigen/Target Category: Small Organic

Affinity (Kd): 1.7 nM (reported value)

Binding Conditions/Buffer: Tris-buffered saline (25 mM Tris, pH 7.4, 150 mM NaCl) Tris potassium calcium buffer (25 mM Tris, 2.5 mM CaCl2, 100 mM KCl)

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 51

Molecular Weight: 26999.39

Extinction Coefficient: 513200

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Bridonneau, P., et al. "High-Affinity Aptamers Selectively Inhibit Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2)." Journal of Medicinal Chemistry, 41(1998): 778-786.

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