Aptamer Details

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Liver-Specific Ligands (236) (ID# 7595)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: Peptide

Target: Liver-Specific Ligands

Antigen/Target Category: Tissue

Affinity (Kd): n/a nM (reported value)

Binding Conditions/Buffer: Selection Buffer (PBS, 1 M NaCl, and 2% Triton X-100) Wash Buffers (0.1% Sodium Borohydride, 0.1 M Phosphate Buffer) (PBS, 5% BSA, 0.1% cold water fish gelatin, and 5% normal goat serum in PBS) Incubation Buffer (PBS and 1.1% BSA-C)

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: 77% liver uptake

Sequence ():

Length: 7

Molecular Weight: 916.24

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Ludtke et al. "In Vivo Selection and Validation of Liver-Specific Ligands Using a New T7 Phage Peptide Display System." Drug Delivery, 14(2007): 357-369.

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