Aptamer Details

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Bevacizumab-Responsive Peptide (BRP) (ID# 7611)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: Peptide

Target: Bevacizumab-treated Tumor

Antigen/Target Category: Tissue

Affinity (Kd): N/A nM (reported value)

Binding Conditions/Buffer: Intracardiac injection of phage libraries. Amplified phages were partially purified by polyethyleneglycol(PEG) precipitation and resuspended in tris-buffered saline (TBS).

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 12

Molecular Weight: 1583.81

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Cao et al. "Phage display peptide probes for imaging early response to bevacizumab treatment." Amino Acids, 41(2011): 1103-1112.

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