Aptamer Details

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VEGF-KDR (ID# 7624)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: Peptide

Target: VEGF-KDR

Antigen/Target Category: Tissue

IC50: ~80 µM (reported value)

Binding Conditions/Buffer: Binding Buffer: DMEM supplemented with 20 mM HEPES (pH 7.4) and 2 mg/mL gelatin

Binding Temp: 4°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: Reduces VEGF-induced angiogenesis and blocks VEGF-KDR interaction.

Sequence ():

Length: 7

Molecular Weight: 886.11

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Binetruy-Tournaire et al. "Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis." The EMBO Journal, 19(2000): 1525-1533.

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