Aptamer Details

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Angiogenic endothelial cells (ID# 7632)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: Peptide

Target: Aminopeptidase N

Antigen/Target Category: Tissue

Affinity (Kd): N/A nM (reported value)

Binding Conditions/Buffer: Wash buffer in cellular association assays: PBS.
Peptides were also delivered in vivo to mice.

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: Authors conjugated the NGR motif to liposomal doxorubicin and used the conjugate to selectively target xenograft neuroblastoma tumors in mice. See reference for details.

Sequence ():

Length: 3

Molecular Weight: 319.43

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Pastorino et al. "Vascular Damage and Anti-angiogenic Effects of Tumor Vessel-Targeted Liposomal Chemotherapy." Cancer Research, 63(2003): 7400-7409.

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