Aptamer Details

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Islets of Langerhans (ID# 7641)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: Peptide

Target: Islets of Langerhans

Antigen/Target Category: Tissue

Affinity (Kd): N/A nM (reported value)

Binding Conditions/Buffer: In vivo in mice with body temperature maintained at 37 °C.

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: Cyclic through N- and C-terminal disulfide bond.
This peptide aptamer is similar to a region in the N-terminus of the ephrin-A2 ligand and binds to the EphA2 receptor.

Sequence ():

Length: 9

Molecular Weight: 1174.47

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Yao et al. "Targeting Pancreatic Islets with Phage Display Assisted by Laser Pressure Catapult Microdissection." American Journal of Pathology, 166(2005): 625-636.

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