Aptamer Details

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VEGF-Stimulated HUVECs (ID# 7720)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: Peptide

Target: VEGF-Stimulated human umbilical vein endothelial cells (HUVECs)

Antigen/Target Category: Protein

Affinity (Kd): N/A nM (reported value)

Binding Conditions/Buffer: In vivo mice.

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: Contains WAR epitope believed to suppress migration of VEGF-stimulated HUVECs, resulting in suppression of tumor growth.
See also ASS peptide , which also results in suppression of tumor growth.
See also PVV peptide , which is mentioned in the same article, and also results in tumor growth suppression.

Sequence ():

Length: 15

Molecular Weight: 2006.41

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Asai et al. "Isolation of a Novel Peptide Homing to Tumor-Derived Neovasculature That Suppresses Tumor Growth." Biological Pharmaceutical Bulletin, 25(2002): 904-906.

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