Aptamer Details

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Neuropeptide Y (Clone 4.31) (ID# 7805)

Aptamer Chemistry: DNA

Target: Neuropeptide Y (NPY)

Antigen/Target Category: Peptide

Affinity (Kd): 300 nM (reported value)

Binding Conditions/Buffer: Capillary Electrophoresis Separation Buffer: 20 mM Hepes (pH 7.3) with 10 mM NaCl

Binding Temp: RT°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: The specificity for neuropeptide Y over the similar human pancreatic polypeptide (hPP; ~50% sequence homology)was 42-fold.

Sequence ():

Length: 80

Molecular Weight: 24737.1

Extinction Coefficient: 783500

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

S.D. Mendonsa and M.T. Bowser. In vitro selection of aptamers with affinity for neuropeptide Y using capillary electrophoresis. J. Am. Chem. Soc. 127(2005): 9382-9383.

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