Aptamer Details

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Influenza B Hemagglutinin (A20) (ID# 7808)

Aptamer Chemistry: RNA

Target: Influenza B Hemagglutinin (HA)

Antigen/Target Category: Protein

Affinity (Kd): 720 pM (reported value)

Binding Conditions/Buffer: Binding Buffer: 50 mM Tris-HCl, pH 7.5, 25 mM NaCl, 5 mM MgCl₂.

Binding Temp: RT°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: No binding observed with Influenza A/Panama and A/Aichi strains.

Comments: This aptamer inhibited HA-mediated membrane fusion in human red blood cell ghost membranes.

Sequence ():

Length: 114

Molecular Weight: 36951.24

Extinction Coefficient: 1096100

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

S. Gopinath et al. An efficient RNA aptamer against human influenza B virus hemagglutinin. J. Biochem. 139(2006): 837-846.

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