Aptamer Details

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A15 (ID# 8102)

Aptamer Chemistry: RNA

Target: Brain Endothelia Cell

Antigen/Target Category: Cells

Affinity (Kd): 48.74 ± 3.11 nM (reported value)

Binding Conditions/Buffer: 10 mmol/l HEPES, pH 7.4, 50 mmol/l NaCl, 1 mmol/l MgCl2, 1 mmol/l CaCl2, 0.01% bovine serum albumin

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 71

Molecular Weight: 21775.7

Extinction Coefficient: 650400

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL. In vivo SELEX for Identification of Brain-penetrating Aptamers. Mol Ther Nucleic Acids. 2013;2(1):e67. Published 2013 Jan 8. doi:10.1038/mtna.2012.59

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