Aptamer Details

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CBSA-5335 LF (ID# 8119)

Aptamer Chemistry: DNA

Target: Cocaine

Antigen/Target Category: Small Organic

Affinity (Kd): 36 nM (reported value)

Binding Conditions/Buffer: 10% saliva in 10 mM Tris, 0.1 mM MgCl2, pH 7.4

Binding Temp: 23°C

Refolding Protocol: N/A

Specificity: Demonstrated specificity to cocaine over benzoylecgonine, anhydroecgonine methyl ester, cocaethylene and nicotine

Comments: The sequence below is one fragment of the cocaine split aptamer that contains two separate fragments, please view "Related Aptamers" for second fragment of the sequence.

Sequence ():

Length: 41

Molecular Weight: 12552.2

Extinction Coefficient: 379500

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Yu, H., Canoura, J., Guntupalli, B., Lou, X., & Xiao, Y. (2017). A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. Chemical Science, 8(1), 131–141. doi:10.1039/c6sc01833e

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