Aptamer Details

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Apta 5 (ID# 8124)

Aptamer Chemistry: DNA

Target: Carcinoembryonic antigen (CEA)

Antigen/Target Category: Protein

Affinity (Kd): 37.8 nM (reported value)

Binding Conditions/Buffer: Not given.

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Apta 5 displayed high specificity and affinity for T84 cells (human carcinoma cell line derived from a lung metastasis of a colon carcinoma).

Sequence ():

Length: 74

Molecular Weight: 21404.8

Extinction Coefficient: 621800

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Melo, M.; Correa, C.; Cunha, P.; Goes, A.; Gomes, D.; Andrade, A. DNA aptamers selection for carcinoembryonic antigen (CEA). Bioorg. Med. Chem. Lett. 2020 May 23; 30(15): 127278. DOI: 10.1016/j.bmcl.2020.127278

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