Aptamer Details

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T2 (ID# 8139)

Aptamer Chemistry: DNA

Target: Plasmodium vivax lactate dehydrogenase (PvLDH)

Antigen/Target Category: Protein

Affinity (Kd): 670 nM (reported value)

Binding Conditions/Buffer: 25 mM Tris·HCl at pH 7.5 containing 0.1 M NaCl and 20 mM imidazole

Binding Temp: 22°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 79

Molecular Weight: 24238.7

Extinction Coefficient: 755500

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Cheung YW, Röthlisberger P, Mechaly AE, et al. Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker. Proc Natl Acad Sci U S A. 2020;117(29):16790-16798. doi:10.1073/pnas.2003267117

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