Aptamer Details

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TEPP (ID# 8175)

Aptamer Chemistry: DNA

Target: Tfr (transferrin receptor) / EpCAM (epithelial cell adhesion molecule)

Antigen/Target Category: Small Organic

Affinity (Kd): Tfr: 110 ± 22.0, EpCAM: 85.6 ± 28.5 nM (reported value)

Binding Conditions/Buffer: 0.1 M sodium acetate (CH3COONa), 0.05 M sodium chloride (NaCl), and 5 mM MgCl2

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: Bifunctional aptamer

Sequence ():

Length: 33

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Macdonald, J., Denoyer, D., Henri, J., Jamieson, A., Burvenich, I. J. G., Pouliot, N., and S. Shigar. 2020. Bifunctional Aptamer–Doxorubicin Conjugate Crosses the Blood–Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells. Nucleic Acid Therapeutics 30:2: 117-128. DOI: 10.1089/nat.2019.0807

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