Aptamer Details

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KM41 (ID# 8219)

Aptamer Chemistry: RNA

Target: A-beta40

Antigen/Target Category: Protein

Affinity (Kd): N/A nM (reported value)

Binding Conditions/Buffer: 140 mM NaCL, 2.7 mM KCl, 10 mM Na2HPO4-, 2mM KH2PO4, pH 7.4

Binding Temp: 23°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Researchers noted that generated aptamers have low specificity but high sensitivity.

Comments: N/A

Sequence ():

Length: 37

Molecular Weight: 11900

Extinction Coefficient: 373800

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Rahimi F, Murakami K, Summers JL, Chen C-HB, Bitan G (2009) RNA Aptamers Generated against Oligomeric Ab40 Recognize Common Amyloid Aptatopes with Low Specificity but High Sensitivity. PLoS ONE 4(11): e7694.

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