Aptamer Details

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HSM01 (ID# 8235)

Aptamer Chemistry: DNA

Target: Human Skeletal Muscle Cells

Antigen/Target Category: Cells

Affinity (Kd): 109.5 nM (reported value)

Binding Conditions/Buffer: Binding buffer: Dulbecco’s phosphate-buffered saline (D-PBS) supplemented with 4.5 g/L of glucose, 5 mmol/L of MgCl2, 0.1 mg/mL of yeast tRNA, and 1 mg/mL of BSA.

Binding Temp: 4°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Specific to human skeletal muscle cells (HSKMCs); counter target is human umbilical vein endothelial cells (EA. hy926 cells)

Sequence ():

Length: 80

Molecular Weight: 26400

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Shuming Sun, Han Liu, Yan Hu, Yanpeng Wang, Mingri Zhao, Yijun Yuan, Yafei Han, Yingying Jing, Jin Cui, Xiaoxiang Ren, Xiao Chen, Jiacan Su, Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle, Bioactive Materials, Volume 20, 2023, Pages 166-178, ISSN 2452-199X, https://doi.org/10.1016/j.bioactmat.2022.05.016. (https://www.sciencedirect.com/science/article/pii/S2452199X22002377)

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