Aptagen, LLC
DNA
BACE1
Protein
68.6 nM (reported value)
Selection Buffer: 5 M guanidine-HCl in 50 mM Tris
°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Apt A1 (ID# 7051)
5’dGpdCpdAp dApdTpdGp dGpdTpdAp dCpdGpdGp dTpdApdCp dTpdTpdCp dCpdGpdTp dCpdApdTp dCpdApdGp dCpdTpdTp dGpdTpdGp dApdTpdGp dTpdGpdGp dApdTpdGp dCpdGpdAp dApdCpdTp dGpdCpdAp dApdApdAp dGpdTpdGp dCpdApdCp dGpdCpdTp dApdCpdTp dTpdTpdGp dCpdTpdAp dAp3’
81
22542 g/mole
698200 L/(mole·cm)
47.95%
1.43
32.29
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Zhi-Man Liang, et al. “The BACE1-Specific DNA Aptamer A1 Rescues Amyloid-b Pathology and Behavioral Deficits in a Mouse Model of Alzheimer’s Disease”. 00. 00. 2019.
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