Aptagen, LLC
DNA
Avian Influenza Virus Subtype H5N1
Other
70 nM (reported value)
Tris buffer (20 mM, pH 7.4).
Not given.°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
HBA1 was found to inhibit hemagglutination, which is caused by the virus surface protein hemagglutinin. This aptamer can be used as both a diagnostic and a therapeutic agent for H5N1.
HBA1 (ID# 7187)
5’dApdTpdGpdCpdGpdGpdApdTpdCpdCpdCpdGpdCpdGpdCpdGpdCpdGpdApdCpdCpdGpdTpdGpdTpdCpdApdGpdCpdGpdGpdGpdGpdApdCpdTpdApdGpdCpdGpdGpdTpdGpdTpdApdGpdCpdGpdCpdGpdApdApdGpdCpdTpdTpdGpdCpdGpdCp3’
60
18601 g/mole
559900 L/(mole·cm)
70.00%
1.79
33.22
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Kim, S.; Choi, J.; Kim, A.; Lee, S.; Yoon, M. Development of ssDNA Aptamers for Diagnosis and Inhibition of the Highly Pathogenic Avian Influenza Virus Subtype H5N1. Biomolecules 2020 July 28; 10(8): 1116. DOI: 10.3390/biom10081116.
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