Aptagen, LLC
Anti Influenza NS1 protein (ID# 7868)
DNA
NS1
Protein
19.91 nM (reported value)
50 mM Tris/Cl (pH 8.0), 150 mM NaCl, 1.5 mM MgCl2, 2 mM DTT and 1% (w/v) BSA
23°C
95C for 10min Denaturing Cold-shock by placing on ice for 10min to renature
ƒ??NS1 is a multifunctional proteinƒ??However, the major role of NS1 is to Antagonize Interferonsƒ??inhibiting the hostƒ??s Innate immunityƒ? (Woo) This aptamer has shown activity that blocks NS1 interaction with hosts (woo)
5'-dGpdCpdApdApdTpdGpdGpdTpdApdCpdGpdGpdTpdApdCpdTpdTpdCpdCpdGpdCpdGpdGpdTpdCpdCpdGpdGpdGpdGpdTpdGpdGpdGpdTpdGpdGpdGpdTpdGpdGpdTpdGpdGpdGpdGpdGpdGpdTpdGpdCpdGpdGpdGpdGpdGpdGpdGpdCpdGpdGpdCpdCpdGpdCpdApdApdApdApdGpdTpdGpdCpdApdCpdGpdCpdTpdApdCpdTpdTpdTpdGpdCpdTpdApdAp-3'
88
27570.81
834900
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Hye-Min Woo. Single-stranded DNA aptamer that specifically binds to the influenza Virus NS1 protein suppresses interferon antagonism
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