Aptamer Details

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Antigen binding fragment of antivesicular stomatitis virus polyclonal antibodies (C5S) (ID# 7755)

Aptamer Chemistry: DNA

Target: Antigen binding fragment (Fab) of antivesicular stomatitis virus (VSV) rabbit polyclonal antibodies

Antigen/Target Category: Protein

Affinity (Kd): N/A nM (reported value)

Binding Conditions/Buffer: DPBS

Binding Temp: RT°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: This aptamer binds to neutralizing antibodies that target the vesicular stomatitis virus (VSV). Incubating Vero cells in an aptamer-VSV-neutralizing antibody mixture recovered viral infectivity by more than 50%.

Sequence ():

Length: 40

Molecular Weight: 12604.2

Extinction Coefficient: 393300

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

D Maharemagic et al. Anti-Fab aptamers for shielding virus from neutralizing antibodies. JACS 134(2012): 17168-17177.

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