Aptamer Details

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C5a (C5C6) (ID# 7718)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: 2'-F-RNA

Target: Human complement C5 component (C5a)

Antigen/Target Category: Protein

Ki: 100 nM (reported value)

Binding Conditions/Buffer: Binding Buffer: Phosphate-buffered saline with 1 mM MgCl₂.
Incubated in the presence or absence of trypsin (between 0.3 and 0.0001 μg/ml)

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 38

Molecular Weight: 12189.15

Extinction Coefficient: 365900

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

G Biesecker et al.. "Derivation of RNA aptamer inhibitors of human complement C5." Immunopharmacology 42(1999):219-230

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