Aptamer Details

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Cyclophilin B (M9-5) (ID# 7702)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: 2'-F-RNA

Target: Cyclophilin B (CypB) pancreatic cell line

Antigen/Target Category: Protein

IC50: 1.5 nM (reported value)

Binding Conditions/Buffer: Buffer F: 20 mM HEPES pH 7.5, 150 mM NaCl, 2mM CaCl₂, and 3 mM MgCl₂

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 71

Molecular Weight: 23031.81

Extinction Coefficient: 674400

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Ray, P. (2012). Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin b as a candidate pancreatic cancer biomarker. J. Clin. Invest., 122(5), 1734-1741. doi: 10.1172/JC162385

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