Aptagen, LLC
dNCL#T1 for Nucleolin (ID# 8958)
DNA
Nucleolin
Protein
0.36 µM (reported value)
Incubated in 10 mM Tris−HCl, 10 mM CuSO4, 10 mM sodium erythorbate solution at 37 C for 6 hours.
37°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
G-quadruplex. Azide modification at 5' end. This is a guide molecule for a nucleolin PROTAC, and is adapted from Nucleolin aptamer AS1411.
dTpdGpdGpdTpdGpdGpdTpdGpdGpdTpdGpdGpdTpdTpdGpdTpdGpdGpdTpdGpdGpdTpdGpdGpdTpdGpdGp
27
8576.5 Da
258300 L/(mole·cm)
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Inducible Degradation of Oncogenic Nucleolin Using an Aptamer-Based PROTAC Miao Chen, Ping Zhou, Yun Kong, Jingrui Li, Yan Li, Yao Zhang, Jie Ran, Jun Zhou, Yan Chen, and Songbo Xie Journal of Medicinal Chemistry 2023 66 (2), 1339-1348 DOI: 10.1021/acs.jmedchem.2c01557
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