Aptamer Details

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Dopamine (DNA version of dopa1.30/c.30) (ID# 7768)

Aptamer Chemistry: DNA

Target: Dopamine

Antigen/Target Category: Small Organic

Affinity (Kd): 0.7 µM (reported value)

Binding Conditions/Buffer: Buffer: 50 mM Tris-HCl (pH 7.4), 5 mM MgCl₂, and 0.5 M

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Aptamer has a similar affinity to related molecules dopamine and norepinephrine but much lower affinity for tyramine

Comments: This aptamer is a homolog of dopamine aptamer dopa1.30/c.30.

Sequence ():

Length: 58

Molecular Weight: 17982.68

Extinction Coefficient: 561000

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

R Walsh and M DeRosa. Retention of function in the DNA homolog of the RNA dopamine aptamer. Biochem. Biophys. Res. Commun. 388(2009): 732-735.

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