Aptamer Details

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ErbB2 Tyrosine Kinase Receptor (Ph-12-1) (ID# 7780)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: Peptide

Target: ErbB2 Tyrosine Kinase Receptor

Antigen/Target Category: Protein

Affinity (Kd): N/A nM (reported value)

Binding Conditions/Buffer: N/A

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Binds strongly to breast cancer cell lines SKBR3, T47D, MCF-7, amd PM-1, prostate Du-145, Glioma U87MG, colon HT-2933, and lung DMS-273. Exhibits some binding to human lymphoblast lymphoma cell line K562.

Sequence ():

Length: 12

Molecular Weight: 1648.88

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Shadidi and Sioud. "Identification of Novel Peptides for the Specific Delivery of Therapeutics into Cancer Cells." The FASEB Journal, 2, (2003): 256-8.

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