Aptamer Details

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G-NB3 (ID# 8113)

Aptamer Chemistry: DNA

Target: Activated Protein C

Antigen/Target Category: Protein

Affinity (Kd): 0.17 nM (reported value)

Binding Conditions/Buffer: 1X PBS

Binding Temp: 22°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 82

Molecular Weight: 25630.6

Extinction Coefficient: 807400

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Hamedani, N. S., Müller, J., Tolle, F., Rühl, H., Pezeshkpoor, B., Liphardt, K., … Pötzsch, B. (2020). Selective Modulation of the Protease Activated Protein C Using Exosite Inhibiting Aptamers. Nucleic Acid Therapeutics. doi:10.1089/nat.2020.0844

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