Aptamer Details

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GHS-R binding peptide (G5-1) (ID# 7713)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: Peptide

Target: growth hormone secretagogue receptor

Antigen/Target Category: Protein

Affinity (Kd): 2.4 nM (reported value)

Binding Conditions/Buffer: 10mM Hepes-Na-OH, pH 7.4: 135 mM NaCl, 5 mM KCl, 2.5 mM CaCl₂, 0.8 mM MgCl₂, 10 mM glucose, 0.2% BSA, and 0.6 mM NaHCO₃. 4 °C.

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 28

Molecular Weight: 3922.6

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

S Ueno et al. In vitro selection of a peptide antagonist of growth hormone secretagogue receptor using cDNA display. PNAS, posted on June 20, 2012, doi: 10.1073/pnas.1203561109 (to appear in print)

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