Aptagen, LLC
HD1-60.29-15dA (ID# 8223)
DNA
Thrombin
Protein
4.9 nM (reported value)
1x PBS, 3mM Magnesium Chloride. 1 ug/uL BSA.
20°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Paper suggests this aptamer as an improvement on the classic thrombin binding aptamer
5'-dGpdGpdTpdTpdGpdGpdTpdGpdTpdGpdGpdTpdTpdGpdGpdApdApdApdApdApdApdApdApdApdApdApdApdApdApdApdApdGpdTpdCpdCpdGpdTpdGpdGpdTpdApdGpdGpdGpdCpdApdGpdGpdTpdTpdGpdGpdGpdGpdTpdGpdApdCpdTp-3'
59
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Müller J, Wulffen B, Pötzsch B, Mayer G. Multidomain targeting generates a high-affinity thrombin-inhibiting bivalent aptamer. Chembiochem. 2007 Dec 17;8(18):2223-6. doi: 10.1002/cbic.200700535. PMID: 17990265.
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