Aptamer Details

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HIV-1 Integrase (P5) (ID# 7534)

Aptamer Chemistry: RNA

Target: HIV-1 Integrase

Antigen/Target Category: Protein

Affinity (Kd): 10 nM (reported value)

Binding Conditions/Buffer: Buffer A (50 mM HEPES, 1 mM DTT, 1 mM APMSF) Binding Buffer (50 mM Na-HEPES (pH 7.5), 250 mM NaCl, 2 mM DTT, 10 mM MnCl2, 5 mM CHAPS)

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 77

Molecular Weight: 24933.1

Extinction Coefficient: 767300

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Allen, P., et al. "Isolation of High-Affinity RNA Ligands to HIV-1 Integrase from a Random Pool." Virology, 209(1995): 327-336.

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