Aptamer Details

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HMGB1 L30 (ID# 8976)

Aptamer Chemistry: DNA

Target: HMGB1

Antigen/Target Category: Protein

Affinity (Kd): 214 ± 26 nM (reported value)

Binding Temp: 23°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: G-quadruplex

Sequence ():

Length: 26

Molecular Weight: 8183.3 g/mole

Extinction Coefficient: 259800 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Ettore Napolitano, Andrea Criscuolo, Claudia Riccardi, Chiara Platella, Rosa Gaglione, Angela Arciello, Domenica Musumeci, Daniela Montesarchio, When annealing is detrimental: The case of HMGB1-targeting G-quadruplex aptamers, International Journal of Biological Macromolecules, Volume 283, Part 1, 2024, 137148, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2024.137148.

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