Aptamer Details

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Human Hepatocellular carcinoma (TLS11a) (ID# 7672)

Aptamer Chemistry: DNA

Target: Human Hepatocellular carcinoma cell line (LH86)

Antigen/Target Category: Cells

Affinity (Kd): 7.16 nM (reported value)

Binding Conditions/Buffer: Binding buffer (PBS containing 5 mM MgCl₂, 4.5 mg/mL glucose, 0.1 mg/mL yeast tRNA, 1 mg/mL BSA)

Binding Temp: 4°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Binds to hepatocellular carcinoma LH86 cell line. Negative control was normal liver cells, Hu1082.

Sequence ():

Length: 63

Molecular Weight: 19339.58

Extinction Coefficient: 589200

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Meng, L. (2012). Targeted delivery of chemotherapy agents using liver cancer-specific aptamer. PloS One, 7(4), doi: 10.1371

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