Aptamer Details

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Human Norovirus SMV-25 (ID# 7933)

Aptamer Chemistry: DNA

Target: Human Norovirus

Antigen/Target Category: Other

Affinity (Kd): 232 nM (reported value)

Binding Conditions/Buffer: 500 ml of binding buffer [consisting of phosphate buffered saline (pH 7.1) supplemented with 100 mg/L CaCl2, 100 mg/L MgCl2 and 0.05% Tween 20] at Room Temperature

Binding Temp: 24°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: See page 8 of source material. Aptamer binds to several strains of the Human Norovirus

Sequence ():

Length: 81

Molecular Weight: 24864.21

Extinction Coefficient: 770500

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Escudero-Abarca BI, Suh SH, Moore MD, Dwivedi HP, Jaykus L-A (2014) Selection, Characterization and Application of Nucleic Acid Aptamers for the Capture and Detection of Human Norovirus Strains. PLoS ONE 9(9): e106805. doi:10.1371/journal.pone.0106805

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