Aptagen, LLC
IR-A48 (ID# 7957)
DNA
Insulin Receptor
Protein
3.5 nM (reported value)
Krebs-Ringer HEPES Buffer. Tested in vivo.
37°C
95 C for 5 minutes, allowed to cool to room temperature.
The 'N's in the structure indicate 5-[N-(1-naphthylmethyl)carboxamide]-2-deoxyuridine (Nap-dU) used in place of Thymine to improve binding efficiency.
5'-dCpdGpdCpdCpdTpdGpdGpdNpdGpdNpdNpdApdApdGpdApdCpdApdApdCpdCpdNpdCpdNpdApdGpdGpdNpdCpdApdGpdGpdCpdGp-3'
33
10129.43
313200
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Yunn N, Koh A, Han S, Lim JH, Park S, et al. (2015) Agonistic Aptamer to the Insulin Receptor Leads to Biased Signaling and Functional Selectivity Through Allosteric Modulation. Nucleic Acids Research 1. doi:10.1093/narlgkv767
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