Aptamer Details

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L15.20.1 HIV Capsid Protein Hexamer Lattice Aptamer (ID# 8970)

Aptamer Chemistry: RNA

Target: Indazole-3-carboxamidesynthetic cannabinoids

Antigen/Target Category: Protein

Affinity (Kd): 733 ± 395 nM (reported value)

Binding Conditions/Buffer: 50 mM Tris-HCl [pH 7.5], 100 mM KCl, 50 mM NaCl, 1 mM MgCl2 at 37°C

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Does not bind soluble Capsid Protein hexamer or Capsid Protein monomer

Sequence ():

Length: 104

Molecular Weight: 33837.4 g/mole

Extinction Coefficient: 1090300 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

A Branched SELEX Approach Identifies RNA Aptamers That Bind Distinct HIV-1 Capsid Structural Components Paige R. Gruenke, Miles D. Mayer, Rachna Aneja, William J. Schulze, Zhenwei Song, Donald H. Burke, Xiao Heng, and Margaret J. Lange ACS Infectious Diseases 2024 10 (8), 2637-2655 DOI: 10.1021/acsinfecdis.3c00708

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