Aptamer Details

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L15.6.1 for HIV-1 Capsid Protein Lattice (ID# 8813)

Aptamer Chemistry: RNA

Target: HIV-1 Capsid Protein Lattice

Antigen/Target Category: Protein

Affinity (Kd): 655 ± 279 nM (reported value)

Binding Conditions/Buffer: pH 7.5. 50 mM Tris-HCl, 100 nM KCl, 50 mM NaCl, 1 mM MgCl2.

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 104

Molecular Weight: 32170.5 g/mole

Extinction Coefficient: 1036600 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

A Branched SELEX Approach Identifies RNA Aptamers That Bind Distinct HIV-1 Capsid Structural Components Paige R. Gruenke, Miles D. Mayer, Rachna Aneja, William J. Schulze, Zhenwei Song, Donald H. Burke, Xiao Heng, and Margaret J. Lange ACS Infectious Diseases 2024 10 (8), 2637-2655 DOI: 10.1021/acsinfecdis.3c00708

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