Aptamer Details

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Mouse Skin Vasculature (ID# 7637)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: Peptide

Target: Mouse hypodermis

Antigen/Target Category: Tissue

Affinity (Kd): N/A nM (reported value)

Binding Conditions/Buffer: In vivo in mice.
Perfusion and washing was performed with DME.

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: The phage displaying this peptide showed 7-fold homing relative to control phage. See also the peptides targeting mouse pancreas vasculature , mouse retina and mouse lung vasculature .

Sequence ():

Length: 13

Molecular Weight: 1467.78

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

D Rajotte et al. " Molecular Heterogeneity of the Vascular Endothelium Revealed by In Vivo Phage Display." Journal of Clinical Investigations, 102(1998): 430-437.

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