Aptamer Details

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N5 (ID# 8080)

Aptamer Chemistry: DNA

Target: PD-L1

Antigen/Target Category: Protein

Affinity (Kd): 441 nM (reported value)

Binding Conditions/Buffer: 136 mM NaCl, 2.6 mM KCl, 4 mM Na2HPO4, 1.8 mM KH2PO4, 2 mM MgCl2, pH 7.4

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 40

Molecular Weight: 12550.2

Extinction Coefficient: 414300

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Li, X., Li, Z., & Yu, H. (2020). Selection of threose nucleic acid aptamers to block PD-1/PD-L1 interaction for cancer immunotherapy. Chemical Communications. doi:10.1039/d0cc06032a

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