Aptamer Details

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Plasminogen Activator Inhibitor-1 (paionap-5) (ID# 7829)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: 2'-F-RNA

Target: Plasminogen Activator Inhibitor-1

Antigen/Target Category: Protein

Affinity (Kd): 1.58 nM (reported value)

Binding Conditions/Buffer: HBS buffer (pH 7.4), 2mM MgCl2, 0.05% Tween 20.

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: E.Coli active PAI-1 variant

Sequence ():

Length: 79

Molecular Weight: 25425.08

Extinction Coefficient: 779600

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Madsen, J.B., et al. "RNA Aptamers as Conformational Probes and Regulatory Agents for Plasminogen Activator Inhibitor-1." Biochemistry, 49, (2010), 4103-4115.

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