Aptamer Details

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Protein Kinase R (PKR) Aptamer (ID# 8744)

RNA
Protein Kinase R (PKR)
Protein
150 pM (reported value)
Refolding Buffer: 333 mM HEPES, pH 8.0, 333 mM NaCl, 33 mM MgCl2. After refolding, incubate with 100 mM of 2-methylnicotinic acid imidazolide (NAI) in DMSO for 10 min at 37°C.
37°C
5 min at 65°C in Refolding Buffer, then slowly cool to 23°C.
Full sequence available soon. Each circular RNA aptamer construct appears to bind 2 PKR protein molecules. 50-150 pmoles of circular RNA aptamer construct appears to have a notable effect on psoriasis plaques in mouse models.
364
120120

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Guo, SK., Liu, CX., Xu, YF. et al. Therapeutic application of circular RNA aptamers in a mouse model of psoriasis. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02204-4

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