Aptamer Details

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Protein Tyrosine Phosphatase (N71yc16) (ID# 7541)

Aptamer Chemistry: RNA

Target: Protein tyrosine phosphatase (PTPase)

Antigen/Target Category: Protein

Affinity (Kd): 18 nM (reported value)

Binding Conditions/Buffer: Selection Buffer (20 mM Tris (pH 7.6), 150 mM NaCl, 5 mM MgCl2, 1 mM dithiothreitol; 100 µl final volume)

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 112

Molecular Weight: 36151.85

Extinction Coefficient: 1126100

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Bell, S., et al. "RNA Molecules That Bind to and Inhibit the Active Site of a Tyrosine Phosphatase." The Journal of Biological Chemistry, 273(1998):14309-14314.

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