Aptamer Details

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R12 (ID# 8217)

Aptamer Chemistry: RNA

Target: Bovine PrP; beta Bovine PrP

Antigen/Target Category: Protein

Affinity (Kd): 8.5; 280 nM (reported value)

Binding Conditions/Buffer: 20 mM Tris-HCl (pH 7.5) and 100 mM NaCl

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: N/A

Comments: N/A

Sequence ():

Length: 12

Molecular Weight: 3903.53

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Kazuyoshi Murakami, Fumiko Nishikawa, Ken Noda, Takashi Yokoyama & Satoshi Nishikawa (2008) Anti-bovine Prion protein RNA aptamer containing tandem GGA repeat interacts both with recombinant bovine prion protein and its β isoform with high affinity, Prion, 2:2, 73-80

Tsukasa Mashima, Akimasa Matsugami, Fumiko Nishikawa, Satoshi Nishikawa, Masato Katahira, Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein, Nucleic Acids Research, Volume 37, Issue 18, 1 October 2009, Pages 6249–6258, https://doi.org/10.1093/nar/gkp647

Mollasalehi N., Francois-Moutal L., Porciani D., Burke D.H., & Khanna M. (2022). Aptamers Targeting Hallmark Proteins of Neurodegeneration. Nucleic Acid Therapeutics, 32(4). https://doi.org/10.1089/nat.2021.0091

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