Aptagen, LLC
R24 (ID# 8215)
RNA
Bovine PrP
Protein
61 nM (reported value)
20 mM Tris-HCl (pH 7.5) and 10 mM KCl
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
N/A
N/A
5'-rGprGprAprGprGprAprGprGprAprGprGprAprGprGprAprGprGprAprGprGprAprGprGprAp-3'
Mashima, T., Lee, JH., Kamatari, Y.O. et al. Development and structural determination of an anti-PrPC aptamer that blocks pathological conformational conversion of prion protein. Sci Rep 10, 4934 (2020).
24
7790.05
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Mashima, T., Lee, JH., Kamatari, Y.O. et al. Development and structural determination of an anti-PrPC aptamer that blocks pathological conformational conversion of prion protein. Sci Rep 10, 4934 (2020).
Mollasalehi N., Francois-Moutal L., Porciani D., Burke D.H., & Khanna M. (2022). Aptamers Targeting Hallmark Proteins of Neurodegeneration. Nucleic Acid Therapeutics, 32(4). https://doi.org/10.1089/nat.2021.0091
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