Aptagen, LLC
SNAP4.74 Aptamer SARS-CoV-2 S Protein (ID# 8563)
DNA
SARS-CoV-2 Spike Protein
Protein
28.1 nM (reported value)
4.5 g/L glucose, 0.1 g/L CaCl2, 0.2 g/L KCl, 0.2 g/L KH2PO4, 0.1 g/L
MgCl2·6H2O, 8 g/L NaCl, 2.1716 g/L Na2HPO4, and 5 mM MgCl2, 1% BSA, 0.1 mg/mL tRNA, 0.1 mg/mL SS DNA, 0.01% Tween-20 @ 25 °C
72.7°C°C
N/A
Binding affinity given for parent aptamer sequence.
Biotinylated version used as the Capture Aptamer in a Sandwich Lateral Flow Assay with a detection limit of 100 pM Spike Protein (6 x 10^9 copies), and a detection limit of 10^6 copies/mL of virus.
5'-dCpdCpdGpdTpdGpdApdCpdGpdCpdApdGpdCpdApdApdGpdGpdGpdTpdApdTpdTpdGpdGpdCpdApdGpdTpdGpdGpdTpdApdGpdGpdTpdApdCpdTpdGpdCpdGpdTpdGpdCpdGpdTpdTpdGpdTpdGpdGpdTpdTpdCpdTpdApdGpdCpdApdTpdGpdTpdTpdTpdApdApdTpdGpdGpdApdCpdApdCpdGpdGp-3'
74 nt
23054.9 g/mole
713600 L/(mole·cm)
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Lucy F. Yang, Nataly Kacherovsky, Nuttada Panpradist, Ruixuan Wan, Joey Liang, Bo Zhang, Stephen J. Salipante, Barry R. Lutz, and Suzie H. Pun. Aptamer sandwich lateral flow assay (AptaFlow) for antibody-free SARS-CoV-2 detection. Analytical Chemistry 2022 94 (20), 7278-7285. DOI: 10.1021/acs.analchem.2c00554
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