Aptamer Details

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Stx 2 B Aptamer (B2) (ID# 8776)

Aptamer Chemistry: DNA

Target: Stx 2 B (Shiga toxin type 2 B Subunit)

Antigen/Target Category: Protein

Affinity (Kd): 50.62 ± 0.038 nM (reported value)

Binding Conditions/Buffer: Binding buffer solution, 4 μM target, and 5 μM aptamer; incubated (2 hours)

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 33

Molecular Weight: 10,890

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Duan M, Ren K, Chen X, Chang Y, Lv Z, Wang Z, Wu S, & Duan N. (2024). "Discovery and design of an aptamer that inhibits Shiga toxin type 2 activity by blocking Stx 2 B subunit-Gb3 interaction." International Journal of Biological Macromolecules, (277)134365. https://doi.org/10.1016/j.ijbiomac.2024.134365

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