Aptamer Details

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Thrombopoietin Receptor (AF12505) (ID# 7661)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: Peptide

Target: Thrombopoietin Receptor

Antigen/Target Category: Protein

Affinity (Kd): 2 nM (reported value)

Binding Conditions/Buffer: N/A

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: The authors also created a dimerized version of AF12505 (AF13948). This peptide aptamer possessed an IC50 of 0.5 nM and EC50 4000 times that of the monomer.

Sequence ():

Length: 14

Molecular Weight: 1754.06

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Cwirla et al. "Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine." Science, 276(1997): 1696-1699.

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