Aptamer Details

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Trypanosoma cruzi-Heparan Parasite Receptor (HS6) (ID# 7570)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: 2'-F-RNA

Target: Trypanosoma cruzi-Heparan Parasite Receptor

Antigen/Target Category: Cells

Affinity (Kd): 40 nM (reported value)

Binding Conditions/Buffer: 50 uM RNA containing 20 mM glucose.

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 107

Molecular Weight: 34422.25

Extinction Coefficient: 1047600

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Ulrich et al. "In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion." The Journal of Biological Chemistry, 277 (2002): 20756-20762.

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