Aptamer Details

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XA-B216 (ID# 8094)

Aptamer Chemistry: DNA

Target: Thy-1 membrane glycoprotein

Antigen/Target Category: Protein

Affinity (Kd): 36 nM (reported value)

Binding Conditions/Buffer: 10 mL of 20 mM Tris buffer (150 mM NaCl, pH 8.0)

Binding Temp: 22°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 42

Molecular Weight: 12868.3

Extinction Coefficient: 380700

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Wang H, Li X, Lai LA, Brentnall TA, Dawson DW, Kelly KA, Chen R, Pan S. X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma. Biochimie. 2021 Feb;181:25-33. doi: 10.1016/j.biochi.2020.11.018. Epub 2020 Nov 23. PMID: 33242496; PMCID: PMC7863625.

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